Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery
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چکیده
منابع مشابه
Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.
The Helicobacter pylori (Hp) type IV secretion system (T4SS) forms needle-like pili, whose binding to the integrin-β1 receptor results in injection of the CagA oncoprotein. However, the apical surface of epithelial cells is exposed to Hp, whereas integrins are basolateral receptors. Hence, the mechanism of CagA delivery into polarized gastric epithelial cells remains enigmatic. Here, we demonst...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2017
ISSN: 1931-3128
DOI: 10.1016/j.chom.2017.09.005